Fig. 6
From: The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells
A proposed pathway of the NEDD4-mediated EGFR-dependent cell migration. Activated EGFR signaling elevates cytoplasmic calcium level and subsequently activates NEDD4. The activated NEDD4 is recruited to the EGFR endosomal complex and the secretary lysosomal vesicles, where NEDD4 interacts with and ubiquitinates the ESCRT complex to facilitate the engulfment of EGFR into MVB and the secretion of lysosmal cathepsin B to extracellular matrix. The secreted lysosomal cathepsin B hydrolyzes cell matrix/junction proteins and promotes cell migration