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Table 1 First generation of mTOR inhibitors

From: The role of RICTOR downstream of receptor tyrosine kinase in cancers

Name Structure
Rapamycin Macrocyclic lactone with two binding moietics
Temsirolimus (CCI-779) Moietics modification: dihydroxylmethyl propionic acid ester
Everolimus (RAD001) Moietics modification: Hydroxylethyl group
Ridaforolimus (AP23573) Moietics modification: Dimethyl phosphate group