Table 1 First generation of mTOR inhibitors
From: The role of RICTOR downstream of receptor tyrosine kinase in cancers
Name | Structure |
|---|---|
Rapamycin | Macrocyclic lactone with two binding moietics |
Temsirolimus (CCI-779) | Moietics modification: dihydroxylmethyl propionic acid ester |
Everolimus (RAD001) | Moietics modification: Hydroxylethyl group |
Ridaforolimus (AP23573) | Moietics modification: Dimethyl phosphate group |