Table 2 Second generation of mTOR inhibitors
From: The role of RICTOR downstream of receptor tyrosine kinase in cancers
dual PI3K/mTOR inhibitors | Selective mTOR inhibitors | ||
|---|---|---|---|
Structure | Name | Structure | Name |
Pyrimidine derivative | PI-103 group include: GDC-0980, GNE-493, GNE-477, PF-04691502 | Pyrimidine derivative | PP242, PP30, INK128 |
Imidazoquinoline derivative | BEZ-235 group include: BGT226, GKS2126458 | Morpholino-linked pyrimidine derivatives | WAY-600, WYE-687, WYE354, KU0063794, AZD8055 |
Quinoxaline derivative | XL765 | Triazine derivative | OSI-027 |