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Table 2 Second generation of mTOR inhibitors

From: The role of RICTOR downstream of receptor tyrosine kinase in cancers

dual PI3K/mTOR inhibitors Selective mTOR inhibitors
Structure Name Structure Name
Pyrimidine derivative PI-103 group include: GDC-0980, GNE-493, GNE-477, PF-04691502 Pyrimidine derivative PP242, PP30, INK128
Imidazoquinoline derivative BEZ-235 group include: BGT226, GKS2126458 Morpholino-linked pyrimidine derivatives WAY-600, WYE-687, WYE354, KU0063794, AZD8055
Quinoxaline derivative XL765 Triazine derivative OSI-027