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Table 1 Summary of key metabolites and molecules affected by TKIs in cancer. Up- or downregulation highly depends on the inhibitor and model of the study used

From: The relevance of tyrosine kinase inhibitors for global metabolic pathways in cancer

Metabolite Function in Sense of Regulation Rerence(s)
Fructose 1,6-bisphosphate glycolysis [27, 34, 38, 41, 45, 48, 49, 58]
Dihydroxyacetone phosphate
3-phosphoglycerate
Glucose (consumption)
Phosphoenolpyruvate glycolysis and gluconeogenesis [22, 27, 38, 45]
Lactate
Glyceraldehyde 3-phosphate
Pyruvate
6-phosphogluconate pentose phosphate pathway [27, 58]
Ribulose-5-phosphate
Ribose-5-phosphate
Xylulose-5-phosphate
D-sedoheptulose 1,7-bisphosphate pentose phosphate pathway [34]
Deoxyribose phosphate
Glucose-6-phosphate glycolysis and PPP [27, 58]
Glutamate amino acid metabolism [27, 30, 34, 45, 74]
Valine
Lysine
Tyrosine
Aspartate
Proline
Threonine
Histidine
Asparagine
Tryptophan
Alanine
NADPH pentose poshosphate pathway [34, 51]
oxidation-reduction pathways
ATP, GTP, CTP, TTP energy metabolism [32, 45, 58]
Fumarate TCA cycle [27, 30]
Malate
Citrate
Arginine amino acid metabolism [74, 76]
Citrate TCA cycle [32]
ATP energy metabolism [60, 62]
Phosphocholine glycerophospholipid metabolism [45, 87,88,89]
  1. Abbreviations: Up-regulation; Down-regulation; TCA cycle Tricarboxylic acid cycle; NADPH Nicotinamide adenine dinucleotide phosphate; ATP Adenosine triphosphate; GTP Guanosine triphosphate; CTP Cytidine triphosphate; TTP Thymidine triphosphate