EML4-ALK fusion and its signaling network. a Diagram shows the fusion of the N-terminal portion of EML4, which contains its basic region, the echinoderm microtubule-associated protein-like protein (HELP) domain, and part of the WD-repeat region, to the intracellular region of ALK, containing the tyrosine kinase domain. The transmembrane (TM) domain is not present in the final fusion product. Reproduced from ref. . b EML4-ALK protein complex network (interactome) constructed using a tandem affinity purification approach followed by mass spectrometry. Reproduced from ref.