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Fig. 5 | Molecular Cancer

Fig. 5

From: The HNF1α-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1

Fig. 5

HNF1A-AS1 suppresses tumourigenicity and metastasis of HCC cells in vivo. a Growth curves of tumours in nude mice injected with Huh-7 cells pre-infected with Lenti-HNF1A-AS1 or control virus (n = 5 in each group). Data represent the mean ± SD. b Images (upper panel) and weight (lower panel) of xenografts derived from Huh-7 cells infected with Lenti-HNF1A-AS1 or control virus. Horizontal line indicates the median value. c HNF1A-AS1 expression levels in the tumour nodules. d HE staining showed a typical trabecular HCC pattern in both the Lenti-HNF1A-AS1 and Lenti-control groups. IHC staining showed the reduction in Ki67 expression in the Lenti-HNF1A-AS1 group compared to that in the Lenti-control group. Scale bars, 200 μm. e Luciferase-labelled MHCC-LM3 cells pre-infected with Lenti-HNF1A-AS1 or control virus were injected into NOD/SCID mice through the tail veins. Luciferase intensity in NOD/SCID mice indicative of metastatic nodules (left). Luciferase signals were measured by the IVIS imaging system (right). f Summary of metastases in different organs

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Molecular Cancer

ISSN: 1476-4598