The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1

Table 2 Univariate and multivariate Cox regression analysis for mortality in stage III and IV GC patients

Variables	Univariate analysis		Multivariate analysis
Variables	HR (95%CI)	P	HR (95%CI)	P
I-III stage
Age (≥55 vs. < 55)	0.832(0.447-1.548)	0.562	0.808(0.416-1.572)	0.53
Sex (Male vs. Female)	0.842(0.453-1.566)	0.587	1.166(0.596-2.284)	0.653
TNM stage (I-III)	2.157(1.359-3.423)	0.001**	2.208(1.368-3.562)	0.001**
MACC1 expression(high vs. low and negative)	2.144(1.160-3.963)	0.015*	2.004(1.054-3.809)	0.034*
MACC1-AS1 expression (high vs. low and negative)	2.194(1.218-3.952)	0.009**	1.913(1.041-3.516)	0.037*
IV stage
Age (≥55 vs. < 55)	1.121(0.493-2.546)	0.786	1.722(0.675-4.395)	0.255
Sex (Male vs. Female)	0.971(0.423-2.226)	0.944	2.162(0.726-6.445)	0.166
MACC1 expression((high vs. low and negative)	2.751(1.155-6.554)	0.022*	2.889(1.122-7.443)	0.028*
MACC1-AS1 expression (high vs. low and negative)	2.572(1.162-5.692)	0.020*	2.509(1.025-6.143)	0.044*

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