Fig. 7
From: Telomerase regulation by the long non-coding RNA H19 in human acute promyelocytic leukemia cells
Hypothetic schematic overview of the relationship between H19 and hTERT in ATRA treated APL cells. ATRA might target telomerase through two distinct processes to ensure a sustained inhibition of telomerase activity, first by decreasing hTERT gene transcription and consequently the amount of hTERT protein, and second, by increasing H19 level, which in turn may impede telomerase assembly and functions