Fig. 8

Combination of NEAT1 and ATGL exhibits improved prognostic accuracy for HCC. a Kaplan-Meier analysis of overall survival in 40 patients indicated that high expression of NEAT1 predicts poor prognosis. The cutoff lines to divide into high and low group was median value. b Kaplan-Meier analysis of overall survival in 40 patients indicated that patients with tumors exhibiting high levels of NEAT1 and high levels of ATGL had lower survival. The cutoff lines to divide into high and low group was median value. c Schematic presentation of the mechanism underlying NEAT1-regulated abnormal lipolysis in hepatocarcinogenesis. NEAT1 regulates ATGL expression via directly bind to miR-124-3p. NEAT1 can influence the HCC proliferation through participating in lipolysis via ATGL. ATGL and its products, DAG and FFA, are responsible for NEAT1-mediated HCC cell growth through PPARα activation