Fig. 3
From: Met is involved in TIGAR-regulated metastasis of non-small-cell lung cancer
TIGAR promotes metastasis of lung cancer in vivo. (a) Representative photos were the coronal, Axial, sagittal co-registered PET/CT and PET images images of a mouse with metastatic lung cancer in the liver from shNC group. Arrows indicate the metastatic tumor on the right of liver, which appears very bright in the images. PET images in color are co-registered with the CT in grayscale. (b) The coronal images of a mouse from shTIGAR group didn’t show significant abnormal 18F-FDG accumulation. (c) Comparison between the tumor and para-tumor in 18F-FDG uptake. (d-g) Tissue sections of intrahepatic (d) and pulmonary (f) metastases were shown, the quantification of intrahepatic (e) and pulmonary (g) metastatic nodules was analyzed by Student’s t-test, the incidence of intrahepatic (e) and pulmonary (g) metastasis was analyzed by using the χ2 test in each group (n = 10). (h) The representative images are hematoxylin and eosin staining, Ki67 staining, TIGAR staining of metastatic foci and precancerous tissue