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Fig. 1 | Molecular Cancer

Fig. 1

From: The long non-coding RNA PTTG3P promotes cell growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in hepatocellular carcinoma

Fig. 1

LncRNA PTTG3P is frequently up-regulated in HCC. (a) Hierarchical clustering analysis of 884 differentially expressed lncRNAs and 979 differentially expressed mRNAs between 3 HCC tumor tissues and paired non-tumor tissues. Up-regulation is shown in yellow and down-regulation is in blue. T, tumor tissues; N, non-tumor tissues. (b) The level of lncRNA PTTG3P was detected in 46 HCC tumor tissues and paired non-tumor tissues by qRT-PCR.U6 was used as a housekeeping gene. (c) The levels of PTTG3P in HCC tissues and adjacent non-tumor tissues was evaluated by ISH assays (cohort 2, n = 90). (d) Representative images of lncRNA PTTG3P expression from HCC tumor tissues and non-tumor tissues by ISH assays. (e) Kaplan-Meier survival analysis of overall survival in 90 patients with HCC (cohort 2) according to PTTG3P expression. Accumulation expression of PTTG3P was unfavorable for HCC prognosis. The log-rank test was used to calculate P values.*P < 0.05

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Molecular Cancer

ISSN: 1476-4598