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Fig. 2 | Molecular Cancer

Fig. 2

From: RETRACTED ARTICLE: LncRNA PVT1 triggers Cyto-protective autophagy and promotes pancreatic ductal adenocarcinoma development via the miR-20a-5p/ULK1 Axis

Fig. 2

Regulation of PVT1 made contributions to autophagy in PDA cells. a PVT1 level was overexpressed by specific lentivirus transfection in Capan-2 and MIA PaCa-2 cells; b PVT1 level was markedly suppressed by specific sh-RNAs in SW1990 and HPAF-II cells; c The ultrastructure of cells with or without up-regulation of PVT1 in Capan-2 and MIA PaCa-2 cells was observed by transmission electron microscopy. Autophagic vacuoles were increased after overexpression of PVT1 in Capan-2 and MIA PaCa-2 cells. Scale bar, 2 μm; d The ultrastructure of cells with or without down-regulation of PVT1 in SW1990 and HPAF-II cells. Autophagic vacuoles were decreased after attenuation of PVT1 expression in SW1990 and HPAF-II cells. Scale bar, 1 μm. Data are presented as the mean ± S.D. (n = 3). * P < 0.05, ** P < 0.01 and *** P < 0.001 by Student’s t-test

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Molecular Cancer

ISSN: 1476-4598