Fig. 4
Genome-wide gene expression analysis on normal primary human oral keratinocytes transfected by normal or cancer-derived exosomes. a OK113 cells were transfected by equal concentration (2 × 1010 particles/well) of each type of exosomes for 48 h prior to microarray analysis using Illumina Human HT-12 v4 Gene Expression BeadChip, exploring 47,231 genes. b Within the top 400 differentially expressed genes (P < 10− 20), exosome (both normal and cancer) exposure led to larger proportion of downregulated genes (61.6%) compared with upregulated genes (38.4%) in recipient cells. c Within the top 400 differentially expressed genes (P < 10− 2), cancer and normal exosomes induced almost equal proportion (50.3 vs 49.7%) of differentially expressed genes in recipient cells