Table 1 BRCA1/2 Mutations in Triple Negative Breast Cancer
From: Therapeutic landscape in mutational triple negative breast cancer
Reference | Race/Ethnicity | TNBC cases | Total TNBC | TNBC with family history | Early onset TNBC | |||
|---|---|---|---|---|---|---|---|---|
BRCA1 prevalence | BRCA2 prevalence | BRCA1 prevalence | BRCA2 prevalence | BRCA1 prevalence | BRCA2 prevalence | |||
Foulkes 2003 [10] | AJa | 72 | 23.6% (17/72) | 0 | _ | _ | _ | _ |
Atchley 2008 [9] | Caucasian/Hispanic/AAb/Asian/AJ | 93 | 34.4% (32/93) | 7.5% (7/93) | _ | _ | _ | _ |
Young 2009 [14] | Caucasian/Hispanic/AA/Asian/AJ | 54 | _ | _ | _ | _ | <40 years 16.7%(9/54) | <40 years 1.9%(1/54) |
Gonzalez 2011 [78] | Caucasian/Hispanic/AA | 77 | 14.3% (11/77) | 3.9% (3/77) | 22.7% (5/22) | 0 | _ | _ |
Comen 2011 [11] | AJ | 64 | 29.7% (19/64) | 9.4% (6/64) | BRCA1/2 prevalence 32.1%(9/28) | <50 years 50%(14/28) | <50 years 7.1%(2/28) | |
Hartman 2012 [79] | Caucasian/Hispanic/AA/Asian | 199 | 6.5% (13/199) | 4.0% (8/199) | 10.2% (11/108) | 4.6% (5/108) | <50 years 9.3%(8/86) | <50 years 5.8%(5/86) |
Greenup 2013 [13] | Caucasian/Hispanic/AA/Asian/AJ | 450 | 23.5% (106/450) | 7.1% (32/450) | _ | _ | <40 years 37.7%(55/146) | <40 years 6.8%(10/146) |
Sharma 2014 [80] | Caucasian/AA/AJ | 207 | 11.1% (23/207) | 4.3% (9/207) | BRCA1/2 prevalence 21.1%(27/128) | BRCA1/2 prevalence: <50 years 27.6%(21/76) | ||
Couch 2015 [6] | Caucasian/Hispanic/AA/Asian | 1824 | 8.5% (155/1824) | 2.7% (49/1824) | 13.4% (72/539) | 3.2% (17/539) | <50 years 13.0%(98/754) | <50 years 3.6%(27/754) |
Tung 2015 [81] | Caucasian/Hispanic/AA/Asian/AJ | 87 | 12.6% (11/87) | 1.1% (1/87) | _ | _ | _ | _ |
Villarreal 2015 [12] | Mexican | 190 | 22.6% (43/190) | 0.5% (1/190) | _ | _ | BRCA1/2 prevalence: <50 years 23.2%(44/190) | |
Wong 2015 [82] | Australian | 439 | 5.9% (26/439) | 3.4% (15/439) | 8.8% (13/147) | 2.7% (4/147) | <40 years 11.9%(7/59) | <40 years 3.4%(2/59) |
Wong 2015 [82] | Polish | 335 | 5.4% (18/335) | 4.5% (15/335) | _ | _ | <40 years 36.4%(4/11) | <40 years 0 |
Gonzalez 2016 [83] | Caucasian/Hispanic/AA/Asian | 105 | 12.4% (13/105) | 1.9% (2/105) | 22.7% (5/22) | 9.1% (2/22) | ≤50 years 20.8%(11/53) | ≤50 years 1.9%(1/53) |
Zhang 2016 [84] | Chinese | 990 | 7.2% (71/990) | 2.2% (22/990) | _ | _ | <50 years 10.6%(53/498) | _ |
Hahnen 2017 [88] | German | 291 | 14.7% (43/291) | 2.4% (7/291) | BRCA1/2 prevalence 28.2%(31/110) | BRCA1/2 prevalence: <40 years 35.4%(23/65) | ||
Sun 2017 [19] | Chinese | 1104 | 7.4% (82/1104) | 3.8% (42/1104) | _ | _ | _ | _ |
Yang 2017 [85] | Malaysians | 88 | 12.5% (11/88) | 9.1% (8/88) | _ | _ | _ | _ |