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Table 1 BRCA1/2 Mutations in Triple Negative Breast Cancer

From: Therapeutic landscape in mutational triple negative breast cancer

Reference Race/Ethnicity TNBC cases Total TNBC TNBC with family history Early onset TNBC
BRCA1 prevalence BRCA2 prevalence BRCA1 prevalence BRCA2 prevalence BRCA1 prevalence BRCA2 prevalence
Foulkes 2003 [10] AJa 72 23.6% (17/72) 0 _ _ _ _
Atchley 2008 [9] Caucasian/Hispanic/AAb/Asian/AJ 93 34.4% (32/93) 7.5% (7/93) _ _ _ _
Young 2009 [14] Caucasian/Hispanic/AA/Asian/AJ 54 _ _ _ _ <40 years
16.7%(9/54)
<40 years
1.9%(1/54)
Gonzalez 2011 [78] Caucasian/Hispanic/AA 77 14.3%
(11/77)
3.9% (3/77) 22.7% (5/22) 0 _ _
Comen 2011 [11] AJ 64 29.7% (19/64) 9.4% (6/64) BRCA1/2 prevalence
32.1%(9/28)
<50 years
50%(14/28)
<50 years
7.1%(2/28)
Hartman 2012 [79] Caucasian/Hispanic/AA/Asian 199 6.5% (13/199) 4.0% (8/199) 10.2% (11/108) 4.6% (5/108) <50 years
9.3%(8/86)
<50 years
5.8%(5/86)
Greenup 2013 [13] Caucasian/Hispanic/AA/Asian/AJ 450 23.5% (106/450) 7.1% (32/450) _ _ <40 years 37.7%(55/146) <40 years
6.8%(10/146)
Sharma 2014 [80] Caucasian/AA/AJ 207 11.1% (23/207) 4.3% (9/207) BRCA1/2 prevalence
21.1%(27/128)
BRCA1/2 prevalence: <50 years
27.6%(21/76)
Couch 2015 [6] Caucasian/Hispanic/AA/Asian 1824 8.5% (155/1824) 2.7% (49/1824) 13.4% (72/539) 3.2% (17/539) <50 years
13.0%(98/754)
<50 years
3.6%(27/754)
Tung 2015 [81] Caucasian/Hispanic/AA/Asian/AJ 87 12.6% (11/87) 1.1% (1/87) _ _ _ _
Villarreal 2015 [12] Mexican 190 22.6% (43/190) 0.5% (1/190) _ _ BRCA1/2 prevalence: <50 years
23.2%(44/190)
Wong 2015 [82] Australian 439 5.9% (26/439) 3.4% (15/439) 8.8% (13/147) 2.7% (4/147) <40 years
11.9%(7/59)
<40 years
3.4%(2/59)
Wong 2015 [82] Polish 335 5.4% (18/335) 4.5% (15/335) _ _ <40 years
36.4%(4/11)
<40 years
0
Gonzalez 2016 [83] Caucasian/Hispanic/AA/Asian 105 12.4% (13/105) 1.9% (2/105) 22.7% (5/22) 9.1% (2/22) ≤50 years
20.8%(11/53)
≤50 years
1.9%(1/53)
Zhang 2016 [84] Chinese 990 7.2% (71/990) 2.2% (22/990) _ _ <50 years
10.6%(53/498)
_
Hahnen 2017 [88] German 291 14.7% (43/291) 2.4% (7/291) BRCA1/2 prevalence
28.2%(31/110)
BRCA1/2 prevalence: <40 years
35.4%(23/65)
Sun 2017 [19] Chinese 1104 7.4% (82/1104) 3.8% (42/1104) _ _ _ _
Yang 2017 [85] Malaysians 88 12.5% (11/88) 9.1% (8/88) _ _ _ _
  1. Abbreviations: a Ashkenazi Jewish; b African American