Fig. 6

KDM4D overexpression promotes GIST cell proliferation and angiogenesis in vivo. a GIST 882 control vector cells or KDM4D cells were subcutaneously injected into Balb/c nude mice. Tumour volume growth curves from day 1 to 30 of treatment are presented. b After 30 days, mice were sacrificed, and tumour weights were examined in the two groups. c Representative tumour images at the end of the experiment are presented. d, e Representative IHC staining of KDM4D and CD31 in the two groups is presented. The right histogram presents tumour microvessel density in the groups. f Western blot revealed the relationship between KDM4D and VEGFA expression in xenograft tumours