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Fig. 7 | Molecular Cancer

Fig. 7

From: Histone demethylase KDM4D promotes gastrointestinal stromal tumor progression through HIF1β/VEGFA signalling

Fig. 7

KDM4D knockdown suppresses GIST cell proliferation and angiogenesis in vivo. a GIST 882 ShNC cells or ShKDM4D cells were subcutaneously injected into Balb/c nude mice. Tumour volume growth curves from days 1 to 25 of treatment are presented. b After 25 days, mice were sacrificed, and tumour weights were examined in the two groups. c Representative tumour images at the end of the experiment are presented. d, e Representative IHC staining of KDM4D and CD31 in the two groups is presented. The right histogram presents tumour microvessel density in the groups. f Western blot reveals the relationship between KDM4D and VEGFA expression in xenograft tumours

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Molecular Cancer

ISSN: 1476-4598