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Table 1 Univariate and multivariate Cox regression analysis of LINC01133 and survival in patients with gastric cancer

From: LINC01133 as ceRNA inhibits gastric cancer progression by sponging miR-106a-3p to regulate APC expression and the Wnt/β-catenin pathway

Clinical variables Univariate analysis P value Multivariate analysis P value
HR 95% CI HR 95% CI
Overall Survival
 Gender (Male vs. Female) 0.776 0.500–1.203 0.257    
 Age (≥60y vs. <60y) 0.978 0.639–1.496 0.918    
 Tumor location (Down vs. Upper/Middle) 0.784 0.512–1.199 0.261    
 Tumor size (≥5 cm vs. < 5 cm) 1.413 0.913–2.185 0.121    
 Differentiation (Poor vs. Moderate/Well) 1.855 0.960–3.587 0.066    
 T stage (T3-T4 vs. T1-T2) 4.126 1.512–11.259 0.006    
 N stage (N2-N3 vs. N0-N1) 2.117 1.304–3.436 0.002    
 TNM stage (III-IV vs. II-I) 3.756 2.040–6.918 < 0.001 2.637 1.405–4.951 0.003
 Distant metastasis (Yes vs. No) 3.533 2.061–6.059 < 0.001 2.133 1.227–3.706 0.007
 Infiltration of peritumoral tissues (Yes vs. No) 2.521 1.646–3.862 < 0.001 1.956 1.269–3.014 0.002
 Peritoneum dissemination (Yes vs. No) 3.725 1.958–7.084 < 0.001    
 LINC01133 expression (high vs. low) 0.381 0.244–0.597 < 0.001 0.517 0.328–0.815 0.005
Progression-Free Survival
 Gender (Male vs. Female) 0.812 0.518–1.273 0.364    
 Age (≥60y vs. <60y) 0.805 0.518–1.250 0.333    
 Tumor location (Down vs. Upper/Middle) 0.722 0.468–1.114 0.141    
 Tumor size (≥5 cm vs. < 5 cm) 1.210 0.782–1.872 0.391    
 Differentiation (Poor vs. Moderate/Well) 1.127 0.635–2.001 0.682    
 T stage (T3-T4 vs. T1-T2) 5.979 1.887–18.945 0.002    
 N stage (N2-N3 vs. N0-N1) 2.419 1.463–4.000 0.001    
 TNM stage (III-IV vs. II-I) 3.511 1.941–6.351 < 0.001 2.493 1.352–4.595 0.003
 Distant metastasis (Yes vs. No) 3.052 1.706–5.459 < 0.001 1.855 1.024–3.360 0.042
 Infiltration of peritumoral tissues (Yes vs. No) 2.381 1.532–3.699 < 0.001 1.792 1.146–2.802 0.011
 Peritoneum dissemination (Yes vs. No) 2.210 1.010–4.835 0.047    
 LINC01133 expression (high vs. low) 0.345 0.217–0.547 < 0.001 0.460 0.287–0.736 0.001
  1. NOTE: TNM tumour node metastasis. HR hazard ratio, CI confidence interval. The bold type represents P values smaller than 0.05