LINC01133 as ceRNA inhibits gastric cancer progression by sponging miR-106a-3p to regulate APC expression and the Wnt/β-catenin pathway

Yang, Xian-Zi; Cheng, Tian-Tian; He, Qing-Jun; Lei, Zi-Ying; Chi, Jun; Tang, Zhen; Liao, Quan-Xing; Zhang, Hong; Zeng, Li-Si; Cui, Shu-Zhong

doi:10.1186/s12943-018-0874-1

Molecular Cancer

Table 1 Univariate and multivariate Cox regression analysis of LINC01133 and survival in patients with gastric cancer

From: LINC01133 as ceRNA inhibits gastric cancer progression by sponging miR-106a-3p to regulate APC expression and the Wnt/β-catenin pathway

Clinical variables	Univariate analysis		P value	Multivariate analysis		P value
Clinical variables	HR	95% CI	P value	HR	95% CI	P value
Overall Survival
Gender (Male vs. Female)	0.776	0.500–1.203	0.257
Age (≥60y vs. <60y)	0.978	0.639–1.496	0.918
Tumor location (Down vs. Upper/Middle)	0.784	0.512–1.199	0.261
Tumor size (≥5 cm vs. < 5 cm)	1.413	0.913–2.185	0.121
Differentiation (Poor vs. Moderate/Well)	1.855	0.960–3.587	0.066
T stage (T3-T4 vs. T1-T2)	4.126	1.512–11.259	0.006
N stage (N2-N3 vs. N0-N1)	2.117	1.304–3.436	0.002
TNM stage (III-IV vs. II-I)	3.756	2.040–6.918	< 0.001	2.637	1.405–4.951	0.003
Distant metastasis (Yes vs. No)	3.533	2.061–6.059	< 0.001	2.133	1.227–3.706	0.007
Infiltration of peritumoral tissues (Yes vs. No)	2.521	1.646–3.862	< 0.001	1.956	1.269–3.014	0.002
Peritoneum dissemination (Yes vs. No)	3.725	1.958–7.084	< 0.001
LINC01133 expression (high vs. low)	0.381	0.244–0.597	< 0.001	0.517	0.328–0.815	0.005
Progression-Free Survival
Gender (Male vs. Female)	0.812	0.518–1.273	0.364
Age (≥60y vs. <60y)	0.805	0.518–1.250	0.333
Tumor location (Down vs. Upper/Middle)	0.722	0.468–1.114	0.141
Tumor size (≥5 cm vs. < 5 cm)	1.210	0.782–1.872	0.391
Differentiation (Poor vs. Moderate/Well)	1.127	0.635–2.001	0.682
T stage (T3-T4 vs. T1-T2)	5.979	1.887–18.945	0.002
N stage (N2-N3 vs. N0-N1)	2.419	1.463–4.000	0.001
TNM stage (III-IV vs. II-I)	3.511	1.941–6.351	< 0.001	2.493	1.352–4.595	0.003
Distant metastasis (Yes vs. No)	3.052	1.706–5.459	< 0.001	1.855	1.024–3.360	0.042
Infiltration of peritumoral tissues (Yes vs. No)	2.381	1.532–3.699	< 0.001	1.792	1.146–2.802	0.011
Peritoneum dissemination (Yes vs. No)	2.210	1.010–4.835	0.047
LINC01133 expression (high vs. low)	0.345	0.217–0.547	< 0.001	0.460	0.287–0.736	0.001

NOTE: TNM tumour node metastasis. HR hazard ratio, CI confidence interval. The bold type represents P values smaller than 0.05

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