Fig. 3

Molecular consequence of the novel t(5;21)(q13;q22) translocation. a The RUNX1 P2 promoter is restrained by a long-range intronic silencer involving SNAG repressors and their corepressor LSD1 for tightly regulated gene expression in myeloid cells. b The t(5;21) breaks RUNX1 upstream of the P2 promoter. This will disrupt the long-range transcriptional control, resulting in unrestrained P2 expression. It is possible that the increased P2 expression activates the P1 promoter on the native chromosome through a positive feedback loop, leading to the concomitant increase in P1 transcription. POL, RNA polymerase; TFs, transcription factors