Table 1 The Relationship of PDEF expression alone and AR and PDEF co-expression with various clinicopathological parameters and other biomarkers in the 100 ER-negative breast cancer cases
Variable | PDEF expression (%) | P value | AR/PDEF expression (%) | P value | ||
|---|---|---|---|---|---|---|
Negative 40 (40.0) | Positive 60 (60.0) | AR+PDEF+ 55 (55.5) | Others 45 (45.0) | |||
Age | ||||||
≤ 49 | 19 (36.5) | 33 (63.5) | 0.298 | 30 (57.7) | 22 (42.3) | 0.359 |
> 49 | 21 (43.8) | 27 (56.2) | 25 (52.1) | 23 (47.9) | ||
Tumor size | ||||||
< 2 cm | 12 (44.4) | 15 (55.6) | 0.841 | 14 (51.9) | 13 (48.1) | 0.803 |
2~ 5 cm | 18 (37.5) | 30 (62.5) | 29 (60.4) | 19 (39.6) | ||
> 5 cm | 10 (40.0) | 15 (60.0) | 12 (48.0) | 13 (52.0) | ||
Menopausal status | ||||||
No | 18 (42.9) | 24 (57.1) | 0.385 | 22 (52.4) | 20 (47.6) | 0.403 |
Positive | 22 (37.9) | 36 (62.1) | 33 (56.9) | 25 (43.1) | ||
Grade | ||||||
1 | 5 (71.4) | 2 (28.6) | 0.032a | 2 (28.6) | 5 (71.4) | 0.053 |
2 | 17 (45.9) | 20 (54.1) | 18 (48.6) | 19 (51.4) | ||
3 | 18 (32.1) | 38 (67.9) | 35 (62.5) | 21 (37.5) | ||
pTNM stage | ||||||
TNM I | 12 (75.0) | 4 (25.0) | 0.011a | 4 (25.0) | 12 (75.0) | 0.047a |
TNM II | 21 (34.4) | 40 (65.6) | 37 (60.7) | 24 (39.3) | ||
TNM III | 7 (30.4) | 16 (69.6) | 14 (60.9) | 9 (39.1) | ||
Lymphatic metastasis | ||||||
No | 34 (61.8) | 21 (38.2) | < 0.001a | 22 (52.4) | 20 (47.6) | 0.403 |
Positive | 6 (13.3) | 39 (86.7) | 33 (56.9) | 25 (43.1) | ||
AR | ||||||
Negative | 26 (83.9) | 5 (16.1) | < 0.001a | – | – | – |
Positive | 14 (20.3) | 55 (79.7) | – | – | ||
PR | ||||||
Negative | 36 (41.4) | 51 (58.6) | 0.341 | 46 (52.9) | 41 (47.1) | 0.211 |
Positive | 4 (30.8) | 9 (69.2) | 9 (69.2) | 4 (30.8) | ||
HER2 | ||||||
Negative | 8 (26.7) | 22 (73.3) | 0.058 | 21 (70.0) | 9 (30.0) | 0.039a |
Positive | 32 (45.7) | 38 (54.3) | 34 (48.6) | 36 (51.4) | ||
Ki-67 | ||||||
< 20% | 7 (31.8) | 15 (68.2) | 0.263 | 14 (63.6) | 8 (36.4) | 0.250 |
≥ 20% | 33 (42.3) | 45 (57.7) | 41 (52.6) | 37 (47.4) | ||
P53 | ||||||
Negative | 17 (33.3) | 34 (66.7) | 0.118 | 31 (60.8) | 20 (39.2) | 0.162 |
Positive | 23 (46.9) | 26 (53.1) | 24 (49.0) | 25 (51.0) | ||
VEGF | ||||||
Negative | 12 (54.5) | 10 (45.5) | 0.092 | 10 (45.5) | 12 (54.5) | 0.218 |
Positive | 28 (35.9) | 50 (64.1) | 45 (57.7) | 33 (42.3) | ||