Fig. 1

BDNF mRNA expression in MPM tumors and prognostic value. a, b Data from frozen MPM tumors samples collection a mRNA expression of BDNF in MPM tumors and normal pleura. Red bars correspond to median. ***p < 0.001. b Overall survival of MPM patients. Patients were separated in “high expression” and “low expression” groups based on the BDNF mRNA expression median and differences in survival between two groups are assessed by log-rank tests. c-e) Data from TCGA database. c mRNA expression of BDNF in MPM tumors, lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Red bars correspond to median. ***p < 0.001. d Overall survival of MPM patients. Patients were separated in “high expression” and “low expression” groups based on the BDNF mRNA expression median and differences in survival between two groups are assessed by log-rank tests. e Expression of BDNF mRNA in 37 different cancers. Arrow indicates mesothelioma BDNF expression. Black horizontal line corresponds to median of BDNF mRNA expression in MPM samples