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Table 1 Treg subtypes and functions

From: Effects of tumor metabolic microenvironment on regulatory T cells

Treg classification Treg subtype Stimulus factor Secretion factor Biological role
Natural Tregs (nTregs) CD4 + CD25 + Foxp3 + nTregs Antigen Perforin, Granzyme B Curbs the occurrence of autoimmune diseases and induces transplant tolerance
Inducible Tregs (iTregs) CD4 + CD25 + Foxp3 + iTregs TGF-β, IL-2 IL-10, IL-35, TGF-β Maintains the stability of the internal environment, curbs the occurrence of autoimmune diseases, anti-tumor immunity, and anti-infective immunity
CD4 + CD25-Foxp3- Tr1 IL-10 IL-10, TGF-β Inflammatory autoimmunity
CD4 + CD25-Foxp3+ Th3 TGF-β TGF-β Participates in oral tolerance and mucosal immunity