Table 1 Treg subtypes and functions
From: Effects of tumor metabolic microenvironment on regulatory T cells
Treg classification | Treg subtype | Stimulus factor | Secretion factor | Biological role |
|---|---|---|---|---|
Natural Tregs (nTregs) | CD4 + CD25 + Foxp3 + nTregs | Antigen | Perforin, Granzyme B | Curbs the occurrence of autoimmune diseases and induces transplant tolerance |
Inducible Tregs (iTregs) | CD4 + CD25 + Foxp3 + iTregs | TGF-β, IL-2 | IL-10, IL-35, TGF-β | Maintains the stability of the internal environment, curbs the occurrence of autoimmune diseases, anti-tumor immunity, and anti-infective immunity |
CD4 + CD25-Foxp3- Tr1 | IL-10 | IL-10, TGF-β | Inflammatory autoimmunity | |
CD4 + CD25-Foxp3+ Th3 | TGF-β | TGF-β | Participates in oral tolerance and mucosal immunity |