BRD4 and Cancer: going beyond transcriptional regulation

Donati, Benedetta; Lorenzini, Eugenia; Ciarrocchi, Alessia

doi:10.1186/s12943-018-0915-9

Molecular Cancer

Table 1 Key BRD4 target genes in normal and tumor cells

From: BRD4 and Cancer: going beyond transcriptional regulation

	Gene function	Model	Reference
Embryonic cells
Oct4	Embryonic development and stem cells pluripotency	mESC	Di Micco R, et al. Cell Rep 2014 [17]
Xite	Regulator of X- chromosome inactivation	mESC	Di Micco R, et al. Cell Rep 2014 [17]
Tsix	Regulator of X- chromosome inactivation	mESC	Di Micco R, et al. Cell Rep 2014 [17]
Nanog	Embryonic stem cells proliferation and pluripotency	mESC	Wu T, et al. Stem Cell Report 2015 [19]
Sox2	Embryonic development and determination of cells fate	mESC	Wu T, et al. Stem Cell Report 2015 [19]
Osteogenesis
TNFRSF11B	Regulator of osteoblasts differentiation	hFOB	Najafova Z, et al. Nucleic Acids Res 2017 [22]
RUNX2	Regulator of osteoblastic differentiation and skeletal morphogenesis	hFOB	Najafova Z, et al. Nucleic Acids Res 2017 [22]
ALPL	Regulator of osteoblasts differentiation	hFOB	Najafova Z, et al. Nucleic Acids Res 2017 [22]
Adipogenesis
Pparg	Regulator of adipocytes differentiation	mESC	Lee JE, et al. Nat Commun 2017 [21]
Cebpa	Regulator of adipocytes differentiation	mESC	Lee JE, et al. Nat Commun 2017 [21]
Fabp4	Regulator of fatty acids uptake and metabolism	mESC	Lee JE, et al. Nat Commun 2017 [21]
Myogenesis
Myod1	Regulator of muscle cells differentiation	mESC	Lee JE, et al. Nat Commun 2017 [21]
Somatic cells
AURKB	Mediator of cell cycle progression	Human Foreskin Keratinocytes	You J, et al. Mol Cell Biol 2009 [89]
Ran	Regulator of cell cycle progression	Mouse Fybroblast	Dey A, et al. Mol Biol Cell 2009 [14]
Kif5b	Regulator of cell cycle progression	Mouse Fybroblast	Dey A, et al. Mol Biol Cell 2009 [14]
Tgf1	Regulator of cell cycle progression	Mouse Fybroblast	Dey A, et al. Mol Biol Cell 2009 [14]
Ywhah	Regulator of cell cycle progression	Mouse Fybroblast	Dey A, et al. Mol Biol Cell 2009 [14]
Gnb1	Regulator of cell cycle progression	Mouse Fybroblast	Dey A, et al. Mol Biol Cell 2009 [14]
Rad21	Regulator of cell cycle progression	Mouse Fybroblast	Dey A, et al. Mol Biol Cell 2009 [14]
Ctnnd1	Regulator of cell cycle progression	Mouse Fybroblast	Dey A, et al. Mol Biol Cell 2009 [14]
Topo1	Regulator of cell cycle progression	Mouse Fybroblast	Dey A, et al. Mol Biol Cell 2009 [14]
Neuron cells
Fos	Regulation of synaptic plasticity in neurons	Mouse Neurons	Korb E, et al. Nat Neurosci 2015 [90]
Arc	Regulation of synaptic plasticity in neurons	Mouse Neurons	Korb E, et al. Nat Neurosci 2015 [90]
Nr4a1	Regulation of synaptic plasticity in neurons	Mouse Neurons	Korb E, et al. Nat Neurosci 2015 [90]
Cardiac cells
Nppa	Cardiovascular homeostasis	Rat cardiac Myocytes	Stratton MS, et al. Cell Rep 2016 [91]
Nppb	Cardiovascular homeostasis	Rat cardiac Myocytes	Stratton MS, et al. Cell Rep 2016 [91]
Ctgf	Chondrocyte proliferation and differentiation	Rat cardiac Myocytes	Stratton MS, et al. Cell Rep 2016 [91]
Pln	Cardiovascular homeostasis	Rat cardiac Myocytes	Stratton MS, et al. Cell Rep 2016 [91]
Myh6/7	Components of cardiac muscle	Rat cardiac Myocytes	Stratton MS, et al. Cell Rep 2016 [91]
Cancer cells
C-MYC	Proto-oncogene	Multiple Myeloma	Lovén J, et al. Cell 2013 [7]
IGLL5	Regulator of immune response	Multiple Myeloma	Lovén J, et al. Cell 2013 [7]
IRF4	Interferon regulatory factor	Multiple Myeloma	Lovén J, et al. Cell 2013 [7]
XBP1	Post-translational Regulation	Multiple Myeloma	Lovén J, et al. Cell 2013 [7]
PRDM1	Regulator of immune response	Multiple Myeloma	Lovén J, et al. Cell 2013 [7]
PIM2	Proto-oncogene	Retinoblastoma	Rahman S, et al. Mol Cell Biol 2011 [37]
CCND1	Regulator of cell cycle progression	Retinoblastoma	Rahman S, et al. Mol Cell Biol 2011 [37]
DCPS	Regulator of mRNA processing	Retinoblastoma	Rahman S, et al. Mol Cell Biol 2011 [37]
TERT	Regulator of Telomere Homeostasis	Colon Cancer	Akincilar SC, et al. Cancer Discov 2016 [80]
GABPA	Regulator of Mitochondrial function	Colon Cancer	Akincilar SC, et al. Cancer Discov 2016 [80]
KRAS	Proto-oncogene	Glioblastoma	Du Z, et al. Int J Oncol 2018 [92]
BRAF	Proto-oncogene	Glioblastoma	Du Z, et al. Int J Oncol 2018 [92]
CALM2	Regulator of cell cycle progression and proliferation	Glioblastoma	Du Z, et al. Int J Oncol 2018 [92]
ARAF	Proto-oncogene	Glioblastoma	Du Z, et al. Int J Oncol 2018 [92]
MAPK8	Regulator of proliferation,differentiation, transcription and development	Glioblastoma	Du Z, et al. Int J Oncol 2018 [92]
PLCB3	Regulator of signal transduction	Glioblastoma	Du Z, et al. Int J Oncol 2018 [92]
MAPK10	Regulator of proliferation,differentiation, transcription and development	Glioblastoma	Du Z, et al. Int J Oncol 2018 [92]
ADCY6	Regulator of signal transduction	Glioblastoma	Du Z,et al. Int J Oncol 2018 [92]
RUNX2	Regulator of cell proliferation, survival and invasiveness	Thyroid, Breast Cancer	Sancisi V, et al. Nucleic Acids Res 2017 [11]
FOSL1	Regulator of cell proliferation, differentiation and trasformation	Non Small Cell Lung Cancer	Shi J, et al. Molecular Cell 2014 [6]
BCL2	Regulator of apoptosis	Hematological malignancies	Shi J, et al. Molecular Cell 2014 [6]
XRCC5	Involved in DSB DNA repair	Prostate Cancer	Li XY, et al. Cell Rep 2018 [58]
XRCC4	Involved in DSB DNA repair	Prostate Cancer	Li XY, et al. Cell Rep 2018 [58]
NHEJ1	Involved in DSB DNA repair	Prostate Cancer	Li XY, et al. Cell Rep 2018 [58]
WRN	Involved in DNA repair and maintenance of genome stability	Prostate Cancer	Li XY, et al. Cell Rep 2018 [58]
DCLRE1C	Involved in DSB DNA repair	Prostate Cancer	Li XY, et al. Cell Rep 2018 [58]
LIG4	Involved in DSB DNA repair	Prostate Cancer	Li XY, et al. Cell Rep 2018 [58]
ERCC4	Involved in DNA repair	Prostate Cancer	Li XY, et al. Cell Rep 2018 [58]
HMOX1	Involved in oxidative stress response	Prostate Cancer	Hussong H, et al. Cell Death Dis 2014 [93]
SESN3	Involved in oxidative stress response	Prostate Cancer	Hussong H, et al. Cell Death Dis 2014 [93]
HDAC6	Hystone Deacetylase	Prostate Cancer	Hussong H, et al. Cell Death Dis 2014 [93]
KEAP1	Involved in oxidative stress response	Prostate Cancer	Hussong H, et al. Cell Death Dis 2014 [93]
MAPK3	Regulator of proliferation, differentiation, transcription and development	Prostate Cancer	Hussong H, et al. Cell Death Dis 2014 [93]
VIM	Involved in maintenance of cell integrity	Prostate Cancer	Hussong H, et al. Cell Death Dis 2014 [93]
NF-kB signaling pathway genes
TNFα	Proinflammatory cytokine	Non Small Cell Lung Cancer, Akute Myeloid Leukemia	Huang B, et al. Mol Cell Biol 2009 [32]
E-Selectin	Inflammatory response mediator	Non Small Cell Lung Cancer	Huang B, et al. Mol Cell Biol 2009 [32]
IL8	Inflammatory response mediator	THP1	Huang B, et al. Mol Cell Biol 2009 [32]
Estrogen receptor target genes
GREB1	Involved in response to estrogen signalling	Endometrial and breast cancer	Nagarajan S, et al. Cell Rep 2014 [94]
TFF1	Involved in response to estrogen signalling	Endometrial and breast cancer	Nagarajan S, et al. Cell Rep 2014 [94]
Androgen receptor target genes
PSA	Biomarker of prostatic carcinoma released in seminal plasma	Prostate Cancer	Urbanucci A, et a Cell Rep 2017 [95]
CAMKK2	Regulator of signal transduction	Prostate Cancer	Urbanucci A, et a Cell Rep 2017 [95]
UBE2C	Involved in protein ubiquitination regulating cell cycle progression	Prostate Cancer	Urbanucci A, et a Cell Rep 2017 [95]
HOXB13	Transcription factor involved in embryonal development	Prostate Cancer	Urbanucci A, et a Cell Rep 2017 [95]
AURKA	Mediator of cell cycle progression	Prostate Cancer	Urbanucci A, et a Cell Rep 2017 [95]

Back to article page

ISSN: 1476-4598

Contact us

General enquiries: journalsubmissions@springernature.com