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Fig. 7 | Molecular Cancer

Fig. 7

From: Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression

Fig. 7

Clinical relevance of PLCE1-induced NF-κB activation in ESCC. a, b PLCE1 were associated with NF-κB molecules expression in 368 primary human ESCC specimens. Scale bar, 100 μm. c Kaplan-Meier curves of patients with ESCCs with low versus high expression of IκBα, IKK and p65; (P = 0.115 × 10− 3, P = 0.612 and P = 0.715, respectively, log-rank test) d PLCE1 mRNA expression was correlated positively with IKKα, IKKβ, Bcl2L1, and VEGF mRNA expression and negatively with IκBα mRNA expression in published profiles of ESCC (n = 198; P < 0.05; TCGA database of esophageal carcinoma). e Proposed model. Schematic model of the regulatory pathway involving PI-PLCε-NF-κB signaling pathway in ESCC. PLCE1 activates the PI-PLCε-NF-κB signaling pathway, enhances angiogenesis, and inhibits apoptosis, which consequently leads to progression of ESCC

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Molecular Cancer

ISSN: 1476-4598