From: The functional role of integrins during intra- and extravasation within the metastatic cascade
Leukocyte Adhesion Molecule | Leukocyte Subtype | Ligand |
---|---|---|
VLA-4 (α4ß1) | Monocytes [39] Neutrophils in case of sepsis [38] | VCAM-1 MAdCAM-1 JAM-B |
LFA-1 (αLß2) (CD11a/CD18) | Monocytes [43] | ICAM-1 ICAM-2 JAM-A |
α4ß7 (CD49d/ß7) | Lymphocytes (CD4 and CD8 T cells) (mucosal lymphoid nodules) [7, 44] | MAdCAM-1 |
Gp150,95 (αXß2) (CD11c/CD18) | Monocytes Macrophages [45] Granulocytes [46] (Neutrophils [9]) Langerhans cells | iC3b (JAM-C [47]) |
αMß2 (mac-1) (CD11b/CD18) | Monocytes [43] Macrophages [45] Granulocytes [48] (Neutrophils [42]) Langerhans cells [7] | iC3b ICAM-1 ICAM-2 JAM-C |
αDß2 | Macrophages (?) [7] Neutrophils [9] | ICAM-3 |
CD47 | T cell [49] | VCAM-1 ICAM-1 |
L1-CAM | α5ß1 (VLA-5) αVß3 | |
Glycosylated proteins (ß-galactose) | Leukocytes [52] | Galectins |