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Fig. 2 | Molecular Cancer

Fig. 2

From: The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis

Fig. 2

Regulation of FOXO subcellular distribution and activity via PI3K/AKT activation. In the presence of growth factors the PI3K/AKT system is activated and the FOXO-TFs are phosphorylated. This modification creates a docking site for 14–3-3, which excludes FOXOs from the nucleus inhibiting the transactivation of target gene promoters (red arrow). In the contrary, the absence of growth factors and AKT/PI3K activation allows FOXO nuclear translocation and the transactivation of target gene promoters (green arrow). GF: growth factors

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Molecular Cancer

ISSN: 1476-4598