Table 4 The translational application of autophagy inhibitors/ activators in tumor therapy
Drug Names | Autophagy Inhibitors/Activators | Combination Treatment | Tumor Types | Phase of Clinical Trials |
|---|---|---|---|---|
Hydroxychloroquine (HCQ) | Inhibitor | Docetaxel | Metastatic Prostate Cancer | Phase2 |
HCQ | Inhibitor | Gemcitabine and Docetaxel | Recurrent or Refractory Osteosarcoma | Phase2 |
HCQ | Inhibitor | Dabrafenib and Trametinib | Melanoma | Phase2 |
HCQ | Inhibitor | Sirolimus or Vorinostat | Advanced Cancer | Phase1 |
HCQ | Inhibitor | Ixabepilone | Breast Cancer | Phase2 |
HCQ | Inhibitor | Mitoxantrone and Etoposid | Relapsed Acute Myelogenous Leukemia | Phase1 |
CQ | Inhibitor | Radiotherapy with daily temozolomide | Glioblastoma (GBM) | Phase1 |
aspirin (ASA) | Activator | Metformin (MET) | Colorectal Cancer | Phase2 |