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Fig. 1 | Molecular Cancer

Fig. 1

From: Transcriptomic expression profiling identifies ITGBL1, an epithelial to mesenchymal transition (EMT)-associated gene, is a promising recurrence prediction biomarker in colorectal cancer

Fig. 1

Biomarker discovery analysis in this study. ITGBL1 expression was upregulated in various biomarker discovery analysis, a) Primary vs. metastasis tissues, b) patients with vs. without tumor recurrence, and c) normal vs. cancer tissues. d Enrichment plots of GSEA correlation analyses for ITGBL1 with EMT-associated gene sets using the GSE39582 dataset (left). Heatmap for the correlation of ITGBL1 and representative EMT-related genes by GENE-E software (right). ITGBL1 expression is upregulated in the CMS4 subtype of CRCs in the two public datasets, e) GSE39582 dataset, and f) GSE33113 dataset. ***P < 0.001. Relationship between ITGBL1 expression and RFS among patients g) in all stage II CRC patients with the GSE39582 cohort, h) in MSS stage II CRC patients within the GSE39582 cohort, and i) in all stage II CRCs in the GSE33113 cohort

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Molecular Cancer

ISSN: 1476-4598