Fig. 1
From: Axl kinase drives immune checkpoint and chemokine signalling pathways in lung adenocarcinomas
Genes encoding immune checkpoint molecules and chemokine/chemokine receptors were enriched in Axl-highly expressing NSCLC. Correlations of mRNA expressions between AXL and genes encoding PD-L1 (CD274; a, g, m and s), PD-L2 (PDCD1LG2; b, h, n and t), CTLA-4 (CTLA4; c, i, o and u), CXCR4 (CXCR4; d, j, p and v), CXCR6 (CXCR6; e, k, q and w) and CXCL16 (CXCL16; f, l, r and x). Microarray data from three cohorts (discovery cohort (a-f, GSE42127), validation cohort1 (g-l, GSE13213), validation cohort3 (s-x, TCGA Pan-Cancer Atlas) and qRT-PCR data from our cohort of Tohoku University Biobank (m-r) are shown. rp is a Pearson correlation coefficient. The x-y axes indicate log2 transformed expression values of genes indicated