Table 1 Important long non-coding RNA that interact with PI3K signaling in different cancer

CRNDE

Up

Gallbladder carcinoma; Non-small cell lung carcinoma; Colorectal cancer; Gastric cancer; Cervical cancer; Heptaocellular cancer

Cell roliferation, growth, migration, invasion and apoptosis; glucose and lipid metabolism

(Gene expression in PI3K pathway: MMP-9, JUK-1, ERK and AKT)

[60,61,62,63,64,65]

OIP5-AS1

Up

Multiple myeloma; Osteosarcoma

Cell proliferation, cycle and apoptosis; cisplatin resistance,

(miRNA-410, miRNA-340-5p and expression of lysophosphatidic acid acyltransferase)

[201, 213]

CCAT1

Up

Thyroid carcinoma; Squamous cell carcinomas

Cell proliferation, migration, and invasion

(miRNA-143; EGFR expression)

[214, 215]

H19

Up

Retinoblastoma, Melanoma

Cell viability, migration, invasion, and apoptosis

(miRNA-143, RUNX2, Phosphorylation of key kinases)

[216, 217]

HOTAIR

UP

Gastric cancer; Adenocarcinoma of esophagogastric junction; Leukemia; Melanoma; Gliomas

Cell proliferation, metastasis and apoptosis; cisplatin resistance; acquired multidrug resistance to imatinib

(miRNA-143, miRNA-34a, miRNA-152-3p, miRNA-126, miRNA-326, FGF1)

[202, 203, 218,219,220,221,222]

NEAT1

Up

Myeloma; Cervical carcinoma; Gastric cancer

Cell proliferation, viability, migration, invasion, apoptosis, and cell cycle.

(microRNA-17)

[223,224,225,226]

HULC

Up

Bladder cancer; Leukemia; Gliomas; Osteosarcoma; Liver cancer; Gastric cancer

Cell viability, growth, migration, invasion and autophagy

(PTEN, miRNA15a, autophagy-P62, miRNA-122)

[227,228,229,230,231,232]

AB073614

Up

Colorectal cancer

Cell cycle, proliferation, migration, and invasion

[233]

PTTG3P

Up

Hepatocellular carcinoma

Cell proliferation, migration, invasion, tumorigenesis and metastasis

[234]

MALAT1

Up

Cervical cancer; Epithelial ovarian cancer;

Breast cancer; Osteosarcoma; Cholangiocarcinoma; Non-small cell lung carcinoma; Hepatocellular carcinoma; Renal cell carcinoma

Cell proliferation, invasion, metastasis, viability and mobility; stemness-related factor activation; epithelial-to-mesenchymal transition; cisplatin resistance

(PI3Kp85α, miRNA-22-3p, miRNA195, miRNA-124, MiRNA-101-3p, miRNA-129-5p)

[235,236,237,238,239,240,241,242,243,244,245]

ATB

Up

Bladder cancer; Prostate carcinoma

Cell proliferation, migration and invasion; mitogenic; epithelial-mesenchymal transition

(microRNA-126, KRAS,)

[246, 247]

BC087858

Up

Non-small-cell lung cancer

Cells invasion; resistance to EGFR-TKIs

(ZEB1, Snail.)

[248]

Linc00659

Up

Colorectal cancer

Cell growth inhibition and apoptosis

[249]

Linc00152

Up

Lung cancer;

Gallbladder cancer

Cell proliferation, invasion, migration, apoptosis, and G1 phase rates

[250, 251]

Linc00462

Up

Hepatocellular carcinoma

Cell proliferation, invasion and migration

[252]

Linc01296

Up

Prostate cancer; Colorectal cancer

Tumorigensis, cell proliferation, migration, invasion, and liver metastasis; epithelial-mesenchymal transition; chemoresistance to 5-fluorouracil

(miRNA-26a, mucin1, GALNT3)

[253, 254]

Linc003121

Down

Thyroid cancer

Cell proliferation, Invasion, and tumorigenicity

[255]

UCA1

Up

Gastric cancer; Bladder cancer

Cell proliferation, migration, invasion, apoptosis and cell cycle

[256,257,258,259]

ecCEBPA

Up

Gastric cancer; Hepatic cancer

Disease progression

[257, 260]

Ftx

Up

Hepatocellular carcinoma

Cell growth

(miRNA-545, RIG-I)

[261]

RMEL3

Up

Melanoma

Cell survival and proliferation

(PTEN)

[262]

LncARSR

Up

Hepatocellular Carcinoma

Doxorubicin resistance

(PTEN)

[206]

BDLNR

Up

Cervical cancer

Cell proliferation, migration, and death; anti-cancer effects of baicalein

(YBX1, PIK3CA promoter)

[263]

ANRIL

Up

Cervical cancer; Osteosarcoma; Gliomas

Cell proliferation, migration, invasion, and apoptosis

(miRNA-34a, Sirt1)

[264,265,266]

ROR

Up

Non-small-cell lung cancer

Cell proliferation, migration, and invasion; cisplatin resistance

[267]

PlncRNA-1

Up

Colorectal cancer

Cell proliferation, migration, invasion, and apoptosis

[268]

MYD88

Up

Hepatocellular carcinoma;

Cell proliferation and metastasis

(H3K27Ac)

[269]

RP4

Down

Colorectal cancer

Cell proliferation, growth, and early apoptosis

(SH3GLB1, miRNA-7-5p)

[270]

OIP5-AS1

Down

Osteosarcoma, myeloma

Cell growth; cisplatin resistance

(miRNA-340-5p, LPAATbeta, miRNA-410, KLF10)

[201, 213]

MEG3

Down

Endometrial carcinoma; Breast cancer; Cervical cancer; Pancreatic cancer; Lymphoma; Gliomas

Cell proliferation, migration, invasion, metastasis, and apoptosis; autophagy; glycolysis; epithelial-mesenchymal transition; chemoresistance

(Combine directly with PI3K, miRNA-21, cytomembrane translocation of AKT)

[271,272,273,274,275,276,277]

GAS5

Down

Colorectal cancer; Esophageal squamous cell carcinoma; Breast cancer; Malignant pleural mesothelioma; Osteosarcoma; Prostate cancer

Cell proliferation and migration, viability, migration and invasion; apoptotic responses to conventional chemotherapies

(miRNA-203a, TIMP2, miRNA-196a-5p, FOXO1)

[66,67,68,69,70,71,72]

RNA-422

Up

Colorectal cancer

Cell proliferation, migration, and invasion

[278]