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Fig. 3 | Molecular Cancer

Fig. 3

From: A novel lncRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis

Fig. 3

MCM3AP-AS1 knockdown suppresses HCC cell proliferation and cell cycle progression and induces apoptosis in vitro. a The expression of MCM3AP-AS1 was knocked down by two different shRNAs in both HepG2 and Hep3B cells. *P < 0.05 by Student’s t-test versus sh-control. b CCK-8 assay indicated that MCM3AP-AS1 knockdown repressed HCC cell proliferation. *P < 0.05 by ANOVA versus sh-control. c The number of HCC cell colonies was reduced after MCM3AP-AS1 knockdown. *P < 0.05 by Student’s t-test versus sh-control. d The proliferation of HCC cells with MCM3AP-AS1 knockdown was decreased compared to control cells as detected by EdU incorporation assay. *P < 0.05 by Student’s t-test versus sh-control. e Flow cytometry assay revealed that the percentage of apoptotic HCC cells was increased by MCM3AP-AS1 knockdown. *P < 0.05 by Student’s t-test versus sh-control. f MCM3AP-AS1 knockdown led to G1 arrest in both HepG2 and Hep3B cells. *P < 0.05 by Student’s t-test versus sh-control

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Molecular Cancer

ISSN: 1476-4598