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Fig. 1 | Molecular Cancer

Fig. 1

From: A positive feed-forward loop between LncRNA-URRCC and EGFL7/P-AKT/FOXO3 signaling promotes proliferation and metastasis of clear cell renal cell carcinoma

Fig. 1

URRCC is a novel lncRNA involved in renal malignant transformation. a: Comparison of BX649059 expression in 20 paired renal cancer tissues and adjacent non-cancer tissues via qRT-PCR. b: BX649059 expression in ccRCC tissues and normal tissues from TCGA KIRC dataset. c: BX649059 expression was determined via qRT-PCR in 96 renal cancer tissues and 25 unpaired non-cancerous renal tissues. d: URRCC expression in a series of RCC cell lines (OSRC-2, 769-P, ACHN, Caki-1, 786-O and A498) and human normal renal tubular epithelial cell line HK-2. e: RNA FISH analysis of URRCC (green) in adjacent tissues and ccRCC tissues while the nucleuses were stained with DAPI (blue). f: qRT-PCR for URRCC, U6 and β-actin from RNA extracted from cytoplasmic and nuclear fractions. g: Of the enrolled 116 cases, the relative URRCC mRNA levels were tested in convenience of the logistic regression analysis. h: Kaplan–Meier analyses of the correlations between URRCC expression level and overall survival of 116 patients with RCC. The median expression level was used as the cutoff

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Molecular Cancer

ISSN: 1476-4598