Table 3 CircRNAs as liquid biopsy biomarkers in cancer

saliva

OSCC

90 OSCC patients, 70 OLK subjects

hsa_circ_0001874

up

TNM stage, tumor grade

[165]

OSCC

90 OSCC patients, 70 OLK subjects

hsa_circ_0001971

up

TNM stage

[165]

plasma

GC

104 GC patients, 104 healthy individuals

Hsa_circ_0000190

down

tumor diameter, lymphatic metastasis, distal metastasis, TNM stage, CA19–9levels

[163]

GC

20 GC patients, 20 healthy individuals

hsa_circ_0006633

up

distal metastasis, tissue carcinoembryonic antigen level

[167]

GC

45 GC patients, 17 healthy individuals

hsa_circ_0000520

down

CEA expression

[168]

GC

24 GC patients, 14 healthy individuals

hsa_circ_0000673

down

TNM stage

[169]

GC

121 GC patients, 121 healthy individuals

hsa_circ_0001017, hsa_circ_0061276

down

OS, DFS

[170]

ESCC

30 ESCC patients, 25 healthy individuals

Circ-TTC17

up

TNM stage, lymphatic metastasis, OS

[171]

PC

31 PC patients, 31 healthy individuals

circ-LDLRAD3

up

CA19–9, N classification, venous invasion, lymphatic invasion

[172]

BC

57 BC patients, 17 healthy individuals

hsa_circ_0001785

down

histological grade, TNM stage, distant metastasis

[173]

HCC

104 HCC patients, 52 healthy individuals

hsa_circ_0001445

down

AFP level

[174]

GC

102 GC patients, 105 healthy individuals

Hsa_circ_0000181

down

tumor differentiation, carcinoembryonic antigen

[175]

LAC

30 LAC patients, 30 healthy individuals

hsa_circ_0013958

up

TNM stage, lymphatic metastasis

[176]

serum

HCC

64 HCC patients, 30 healthy individuals

circ-ZEB1.33

up

TMN stages, OS

[162]

BCa

197 BCa patients, 97 healthy individuals

hsa_circ_0000285

down

tumor size, differentiation, lymph node metastasis, distant metastasis, TNM stage, OS

[177]

NPC

150 NPC patients, 100 healthy individuals

circRNA_0000285

up

tumor size, differentiation, lymph node metastasis, distant metastasis, TNM stage.

[178]

exosome (serum and urine)

UCB

71 UCB patients, 36 healthy individuals

circPRMT5

up

lymph node metastasis, T and N status, DFS

[166]

UCB

18 UCB patients, 14 healthy individuals

circPRMT5

up

lymph node metastasis, T and N status, DFS

[166]