From: Circular RNAs and their roles in head and neck cancers
CircRNAs | Functions | Proteins | Possible mechanism involved in physiological process and pathophysiologic | Reference |
---|---|---|---|---|
circMbl | Protein reservoirs | Mbl | CircMbl could absorb MBL to terminate its promotion effect on the generation of circMbl, constructing a feedback loop regulating the balance of circMbl and its cognate linear mRNA | [60] |
circRNP | Protein reservoirs | NF90/NF110 | During the viral infection, NF90/NF110 was exported from nucleus by circRNPs and then released to bind to viral mRNAs for antiviral immune response | [59] |
circAmotl1 | Protein reservoirs | c-myc | Circ-Amotl1 induced nuclear translocation of c-myc, promoting c-myc stability and upregulating c-myc targets to accelerate tumorigenesis | [34] |
circAmotl1 | Protein reservoirs | Stat3 | By binding to Stat3, circAmotl1 lead the nuclear translocation of Stat3, accelerating wound healing process via modulating Dnmt3a and miR-17 function | [105] |
circPABPN1 | Protein reservoirs | HuR | CircPABPN1 could suppress the translation of cognate mPABPN1 by binding to HuR, an RBP that could promote the translation of PABPN1 mRNA | [107] |
circDNMT1 | Protein reservoirs | p53 and AUF1 | Both p53 and AUF1 undergo nuclear translocation through interacting with circ-Dnmt1. Nuclear translocated p53 promoted cellular autophagy while AUF1 nuclear translocation resulted in increased Dnmt1 translation | [106] |
circFoxo3 | Interact with RBPs | p21 and CDK2 | CircFoxo3 repressed cell cycle in G1 phase by binding to the cell cycle proteins CDK2 and p21, forming a ternary complex as well as circFoxo3-CDK2 complex and circFoxo3-p21 complex | [110] |
circFoxo3 | Interact with RBPs | ID-1, E2F1, FAK, and HIF1a | CircFoxo3 was mainly located in the cytoplasm interacting with anti-senescent protein ID-1 and E2F1, the anti-stress proteins FAK and HIF1a retained in cytoplasm to abrogate their anti-senescent and anti-stress functions | [111] |
circFoxo3 | Interact with RBPs | p53 and MDM2 | By binding to MDM2 and p53, circFoxo3 facilitated MDM2-induced p53 ubiquitination and subsequent degradation while freeing Foxo3 from being ubiquitinated, thus improved the level of PUMA which induced cell apoptosis | [112] |
CircCcnb1 | Interact with RBPs | H2AX and Bclaf1; H2AX and p53 | In the conditions of p53 was mutant, circ-Ccnb1 could form a complex with H2AX and Bclaf1 to decrease the ability of proliferation and survival but increase the apoptosis; in the conditions of wild-type p53, circCcnb1 bind to H2AX and wild-type p53, avoiding induction of cell death | [113] |