Table 3 The potential circRNA biomarkers in HNCs
From: Circular RNAs and their roles in head and neck cancers
CircRNAs | Chromosome | Gene symbol | Primary sites of cancer | Expression change | Relationships with the clinical features | Number of patients | Cilinical samples | Clinical value | Reference |
|---|---|---|---|---|---|---|---|---|---|
circPVT1 | chr8 | PVT1 | HNSCC | Up | mut-p53, alcohol use | 106 | Tumor tissues | Poor overall survival (dependent on the TP53 mutations) | [137] |
hsa_circ_0008309 | chr2 | CUL3 | OSCC | Down | Pathological differentiation | 45 | Tumor tissues/Non-tumor tissues | Diagnosis biomarker (AUC = 0.764) | [138] |
hsa_circ_001242 | chr10 | TRDMT1 | OSCC | Down | Tumor size, T stage | 40 | Tumor tissues/Non-tumor tissues | Diagnosis biomarker (AUC = 0.784, Sensitivity = 0.725, Specificity = 0.775) | [139] |
hsa_circ_0109291 | chr19 | ZNF714 | OSCC | Up | TNM stage | 51 | Tumor tissues | Poor overall survival | [140] |
hsa_circ_0001874 | chr9 | BICD2 | OSCC | Up | TNM stage and tumor grade | 178 | Saliva from the OSCC patients and healthy controls | Early non-invasive diagnosis biomarker for OSCC in saliva (AUC = 0.863, Sensitivity = 0.744, Specificity = 0.902) | [144] |
hsa_circ_0001971 | chr7 | FAM126A | OSCC | Up | TNM stage | 178 | Saliva from the OSCC patients and healthy controls | Early non-invasive diagnosis biomarker for OSCC in saliva (AUC = 0.845, Sensitivity = 0.756, Specificity = 0.878) | [144] |
hsa_circ_0001874 + hsa_circ_0001971 | – | – | OSCC | – | – | 178 | Saliva from the OSCC patients and healthy controls | Early non-invasive diagnosis biomarker for OSCC in saliva (AUC = 0.922, Sensitivity = 0.927, Specificity = 0.778) | [144] |
hsa_circRNA_100855 | – | – | LSCC | Up | T stage, lymph node metastasis, primary location, clinical stage | 52 | Tumor tissues/Non-tumor tissues | Diagnosis and prognosis biomarker* | [145] |
hsa_circRNA_104912 | – | – | LSCC | Down | T stage, differentiation, lymph node metastasis, clinical stage | 52 | Tumor tissues/Non-tumor tissues | Diagnosis and prognosis biomarker* | [145] |
hsa_circ_0000284 (circHIPK3) | chr11 | HIPK3 | NPC | Up | Clinical stage, distant metastasis | 63 | Tumor tissues | Poor overall survival and distant metastasis-free survival rates | [146] |
has_circ_0000285 | chr11 | HIPK3 | NPC | Up | Tumor size, TNM stage, distant metastasis, tumor grade and lymph node metastasis | 150 | Serums and tumor tissues | Poor overall survival, poor radiosensitivity and serve as independent prognostic factors (HR = 3.03, p = 0.02) | [147] |