Fig. 1

RP11 is increased in CRC cells and tissues. a Heat-maps of lncRNAs that were differentially expressed between stage I samples (a, cancer tissues) and matched adjacent normal samples (b, normal samples) (left) or between stage IV samples and matched adjacent normal samples (right). The colour scale shown on the left illustrates the relative RNA expression levels; red represents high expression, and green represents low expression. b Venn diagram showing the overlapping of 2-fold upregulated lncRNAs between stage I samples and normal samples, stage IV and normal, and stage IV and stage I. c Heat-maps of the 8 lncRNAs upregulated simultaneously between stage I samples and normal samples, between stage IV and normal, and between stage IV and stage I (Red probe targeted lncRNA RP11). d The relative fold of RP11 in 32 paired human colon cancer tissues versus its matched adjacent normal mucosa tissues. e The relative expression of RP11 in colon (left) and rectal (right) cancer tissues and their corresponding adjacent normal tissues based on data available from TCGA database. f The levels of RP11 in CRC cell lines and human colon mucosal epithelial NCM460 cells were measured by qRT-PCR. Data are presented as the mean ± SD from three independent experiments. *p < 0.05 compared with control