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Fig. 2 | Molecular Cancer

Fig. 2

From: CircDLST promotes the tumorigenesis and metastasis of gastric cancer by sponging miR-502-5p and activating the NRAS/MEK1/ERK1/2 signaling

Fig. 2

Knockdown of circDLST inhibited the proliferation and colony formation of GC cells. a The genomic loci of the DLST gene and circDLST. b qRT-PCR analysis of the expression levels of DLST and circDLST after treatment with RNase R in GC cell lines. c qRT-PCR analysis of the knockdown efficiency of sh-circDLST after the transfection for 48 h in MKN-28 and MKN-45 cells. d MTT analysis of the cell viability after the transfection of sh-circDLST or sh-NC in MKN-28 and MKN-45 cells. e Colony formation analysis of the cell colony number after the transfection of sh-circDLST or sh-NC in MKN-28 and MKN-45 cells. f EdU analysis of the DNA synthesis after the transfection of sh-circDLST or sh-NC in MKN-28 and MKN-45 cells. Bar scale: 125 μm. Data are the means ± SEM of three experiments. *P < 0.05; **P < 0.01

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Molecular Cancer

ISSN: 1476-4598