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Fig. 1 | Molecular Cancer

Fig. 1

From: Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy

Fig. 1

The drug-resistant property of Dox-resistant gallbladder cancer cells is associated with their enhanced autophagic activity. a The sensitivities of Dox-resistant gallbladder cancer cells and their parental cells with Dox were determined by CCK-8 assay. b The protein levels of LC3 and p62 in Dox-resistant gallbladder cancer cells and their parental cells were determined by western blot assay. c Dox-resistant gallbladder cancer cells and their parental cells that stably express the stubRFP-sensGFP-LC3 fusion protein were established and observed by the fluorescence microscope. d The sensitivities of Dox-resistant gallbladder cancer cells and their parental cells under different treatments with Dox were determined by CCK-8 assay. e The nude mice carrying tumors from NOZ/Dox under Dox with or without CQ were shown. Average tumor volume for each group was calculated. The mean ± SD of triplicate experiments were plotted, ***P < 0.001

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Molecular Cancer

ISSN: 1476-4598