Fig. 1
From: MED12 exerts an emerging role in actin-mediated cytokinesis via LIMK2/cofilin pathway in NSCLC
MED12 mutation and expression in human NSCLC tissues. a Next-Generation Sequencing consequence of RT-PCR products from 40 samples of NSCLC tissue and blood indicated no mutation at exons of MED12 gene. Color stripes: exons; gray stripes: introns. b Representative images of negative (−), weak (+), moderate (++), strong (+++) MED12 IHC staining in NSCLC tissues. Scale bar: 50 μm. c Representative image of MED12 IHC staining in the tumor tissue and adjacent normal lung epithelial tissue. Abbreviation N denoted nuclear location of MED12. Scale bar: 50 μm. d Western blotting analysis of MED12 expression in 6 matched NSCLC tumor tissues lysates and normal lung tissues lysates. T: tumor tissue, N: normal lung tissue. e Quantification of MED12 expression in 73 samples of tumorous and adjacent normal lung epithelial tissues. f, g, The Kaplan-Meier plot showed the progression-free survival (PFS) and overall survival (OS) in comparison of patients with high or low MED12 expression