Fig. 1
From: Lung adenocarcinoma-intrinsic GBE1 signaling inhibits anti-tumor immunity
GBE1 prevents CCL5 and CXCL10 expression in LUAD cells. a GO analysis showed the top 20 genes involved in shGBE1 A549 cells compared to control based on the RNA-seq data. b Heatmap of relative mRNA expression for cytokine-cytokine receptor interaction related genes in shGBE1 A549 cells compared to control. Concentrations of cytokine-cytokine receptor interaction related core-enriched genes in siGBE1 (c) and (d) shGBE1 A549 cells compared to control analyzed using a multiplex assay (siGBE1: 2 × 104 cells/well, shGBE1: 5 × 104 cells/well). e Real-time PCR and (f) ELISA analysis of CCL5 and CXCL10 expression in shGBE1 A549 cells compared to control