Fig. 5
From: Lung adenocarcinoma-intrinsic GBE1 signaling inhibits anti-tumor immunity
The effect of GBE1 on PD-L1 expression. a The correlation analysis of TCGA data for PD-L1 with CD8, CCL5, CXCL10, and IFN response signature expression across primary LUAD samples. The RNA-seq (b), mRNA (c) and protein (d) expression of PD-L1 in shGBE1 A549 cells compared to control. e and f Flow cytometry analysis of PD-L1 in shGBE1 A549 cells compared to control with or without IFN-γ treatment. g The real-time PCR analysis of PD-L1 in A549 cells treated with poly(I:C). h and i IHC interaction plots of serial sections derived from patients with LUAD (n = 30) were stained for GBE1 and PD-L1. j Immunofluorescence analysis of GBE1 and PD-L1 expression in LUAD tissues