Fig. 6

Blockade of GBE1 signaling combined with anti-PD-L1 antibody inhibits tumor growth in vivo. a Scheme of the in vivo experimental procedure detailed in “Materials and Methods” and “Results” section. b Tumor growth was measured twice a week until mice were sacrificed (n = 20). Tumor volumes were measured from day 14 to day 33 after cell implantation. Tumor weights were measured at day 33 after xenograft collection. Flow cytometry analysis of CD8⁺CD3⁺ T cell frequency (c) and IFN-γ⁺CD8⁺ or Granzyme B⁺CD8⁺ T cell frequency (d) in the tumor xenografts. e Illustration of CD8, CCL5 and CXCL10 IHC staining of sections from one representative xenograft