Fig. 2

Beclin-1 signaling pathway regulated autophagy and EMT. The Beclin-1 gene triggers autophagy by forming the PI3K complex and prohibiting EMT through down-regulating ZEB1, WNT1, and NF-κB. Additionally, Beclin-1-induced autophagy accelerated EMT by up-regulating vimentin and Twist expression and decreasing E-cadherin expression