Fig. 3From: Exosomal circRNAs: biogenesis, effect and application in human diseasesThe role of exosomal circRNAs in metastasis. Exosomal circPDE8A acted as a competing endogenous RNA sponge with miR-338 and induced invasive growth via the MACC1, MET, ERK, and AKT pathways. Eventually, this process led to an increase in vascular endothelial permeability and promoted pancreatic tumor hepatic metastasisBack to article page