Table 1 Univariate analyses of factors associated with bone metastasis in 252 HCC patients
Variable | Bone metastasis | |
|---|---|---|
HR (95% CI) | P | |
Age (≤51 versus > 51 years) | 1.021 (0.520–2.004) | 0.952 |
Gender (male versus female) | 1.109 (0.429–2.866) | 0.830 |
HBsAg (negative versus positive) | 0.735 (0.333–1.625) | 0.447 |
HCV-Ab (negative versus positive) | 1.608 (0.219–11.829) | 0.641 |
AFP, ng/mL (≤ 20 versus > 20) | 0.597 (0.295–1.206) | 0.150 |
ALT,U/L (≤ 40 versus > 40) | 1.356 (0.648–2.836) | 0.419 |
γ-GT,U/L (≤ 50 versus > 50) | 1.275 (0.650–2.501) | 0.480 |
Liver cirrhosis (no versus yes) | 1.039 (0.430–2.510) | 0.933 |
Child-Pugh score (A versus B) | 2.714 (0.650–11.336) | 0.171 |
Tumor differentiation (I–II versus III–IV) | 0.464 (0.163–1.317) | 0.149 |
Tumor size, cm (≤ 5 versus > 5) | 0.716 (0.358–1.430) | 0.344 |
Tumor number (single versus multiple) | 1.108 (0.482–2.544) | 0.810 |
Tumor encapsulation (complete versus none) | 4.112 (1.791–9.444) | 0.001 |
Vascular invasion (no versus yes) | 13.116 (6.379–26.969) | < 0.001 |
BCLC stage (0-A versus B-C) | 18.099 (8.894–36.834) | < 0.001 |
Lnc34a (negative versus positive) | 9.780 (3.440–27.806) | < 0.001 |