Skip to main content

Table 2 Summary of ovarian cancer exosomal miRNAs involved with metastasis

From: Exosomes promote pre-metastatic niche formation in ovarian cancer

Exosomal miRNAs

Recipient cells

Role/Mechanism

Reference

miR-940, miR-222-3p,miR-21–3p, miR-125 b-5p, miR-181 d-5p

TAMs

M2 phenotype polarization, EOC proliferation and migration

[39,40,41]

miRNA 21 and 29a

ES2 OC cellsLP9 mesothelial cells

Mesothelial cell clearance

[42]

miR-99a-5p

HPMC

Cell invasion through fibronectin and vitronectin upregulation

[43]

MMP1 mRNAs

MeT-5A and HPMC

Destruction of peritoneal mesothelium barrier

[44]

let-7a-f and miR-200a-c

N/A

Correlates with ovarian cancer invasiveness

[45]

  1. Abbreviations: TAMs Tumor-associated macrophages, HPMC Human peritoneal mesothelial cells, OC ovarian cancer, EOC Epithelial ovarian cancer, MMP Matrix metallopeptidase