From: Exosomes promote pre-metastatic niche formation in ovarian cancer
Exosomal miRNAs | Recipient cells | Role/Mechanism | Reference |
---|---|---|---|
miR-940, miR-222-3p,miR-21–3p, miR-125 b-5p, miR-181 d-5p | TAMs | M2 phenotype polarization, EOC proliferation and migration | |
miRNA 21 and 29a | ES2 OC cellsLP9 mesothelial cells | Mesothelial cell clearance | [42] |
miR-99a-5p | HPMC | Cell invasion through fibronectin and vitronectin upregulation | [43] |
MMP1 mRNAs | MeT-5A and HPMC | Destruction of peritoneal mesothelium barrier | [44] |
let-7a-f and miR-200a-c | N/A | Correlates with ovarian cancer invasiveness | [45] |