Table 2 piRNAs as biomarkers in cancer
piRNA | Cancer | Expression in blood | Clinical correlation | ROC curve AUC sensitivity specifity | Reference |
|---|---|---|---|---|---|
piR-651 | Gastric cancer | down | TNM stage, distant metastasis | 0.841 0.709 0.813 | [101] |
piR-823 | down | TNM stage, distant metastasis | 0.822 0.805 0.812 | [101] | |
piR-5937 | Colorectal cancer | down | TNM stage | 0.806 0.718 0.725 | [102] |
piR-28876 | down | TNM stage | 0.8065 0.753 0.700 | [102] | |
piR-54265 | up | TNM stage, survival times and curative efficacy of chemotherapy | 0.811 0.667 0.885 | [45] | |
piR-823 | Renal cell cancer | up | TNM stages | – | [103] |
piR-823 | Multiple myeloma | up | TNM stages | – | [60] |
piR-651 | classical Hodgkin lymphoma | down | the presence of lymphoma | – | [61] |