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Fig. 8 | Molecular Cancer

Fig. 8

From: Circular RNA circ-ZKSCAN1 inhibits bladder cancer progression through miR-1178-3p/p21 axis and acts as a prognostic factor of recurrence

Fig. 8

Overexpression of Circ-ZKSCAN1 Suppresses Proliferation Growth and Invasion of BCa cells in vivo. a-d UM-UC-3 stably expressed circ-ZKSCAN1 or wild-type UM-UC-3 were injected into BALB/C nude mice. (n = 5 for each group) Compare with NC group, tumor weight and volume significantly reduced in overexpressed group. e IHC revealed that the expression of p21 significantly enhanced in overexpressed group, compare to NC group. f-g The luciferase images demonstrated that enforced circ-ZKSCAN1 could inhibited metastasis in the foot pads model. The popliteal lymph nodes was smaller in overexpressed group than in the NC group. (n = 4 for each group) h Western blotting revealed that over-expression of circ-ZKSCAN1 led to increased expression of p21 within xenografted tumors

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