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Fig. 6 | Molecular Cancer

Fig. 6

From: Circ-AKT3 inhibits clear cell renal cell carcinoma metastasis via altering miR-296-3p/E-cadherin signals

Fig. 6

circ-AKT3 inhibits the metastasis of ccRCC in vivo. a-b Bioluminescence imaging of mice 8 weeks after the orthotopically implanted with OSRC-2-Luciferase-circ-AKT3 and OSRC-2-Luciferase-vector (n = 10 per group). Top panel: representative images. Bottom panel: images of metastatic foci of liver, lung, spleen and the metastatic kidney (Kidney(M)) on the other side. c Statistical analysis of mice with liver metastasis in each group. d Total metastatic foci of each mouse counted after dissection. e qRT-PCR analysis of circ-AKT3 and E-cadherin expression in ccRCC metastatic nodules. f-g Immunohistochemistry (IHC) detection of E-cadherin in tumor of mice. Scale bars: 100 μm. Three independent experiments were conducted. **P < 0.01; ***P < 0.001

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