Fig. 1From: Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4Structure of LAG-3, TIM-3, TIGIT, VISTA, B7-H3, and BTLA. All of them were type I transmembrane glycoprotein with a similar structure, including N-terminal IgV domain, a transmembrane domain and a cytoplasmic tail. However, they share distinct signaling motifBack to article page