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Fig. 4 | Molecular Cancer

Fig. 4

From: Extracellular vesicles of carcinoma-associated fibroblasts creates a pre-metastatic niche in the lung through activating fibroblasts

Fig. 4

Integrin α2β1 mediated CAF EV uptake by LFs. a Western blot analysis of integrin expression in CAF-A1/A2 EVs. b Inhibition assay of CAF EV uptake by LFs in vitro. The TC I-15 concentrations tested were 0, 0.5, 1 and 2 μM. c TC I-15 inhibitory effects on the expression of p-Smad3 in LFs induced by CAF-A1/A2 EVs. d TC I-15 inhibitory effects on the expression of FAP, α-SMA and POSTN in LFs induced by CAF-A1/A2 EVs. e TC I-15 inhibitory effects on collagen gel contract promoted by CAF-A1/A2 EVs. Scale bar = 50 μm. * P < 0.05, ** P < 0.01, *** P < 0.001

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Molecular Cancer

ISSN: 1476-4598